Combined Inhibition of JAK/STAT Pathway and Lysine Demethylase 1 as a Novel Therapeutic Strategy in CSF3R/CEBPA Mutant Acute Myeloid Leukemia [LSD1i ChIP-seq]
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资源简介：
The presence of CSF3R mutations are associated with adverse outcomes in CEBPA mutant AML. Here we report that inhibitors of LSD1 reverse the mutant CEBPA-mediated differentiation blockade and exhibit synergy with JAK/STAT inhibitors. Comparison of chromatin landscapes in mouse bone marrow cells retrovirally expressing mutant CSF3R and CEBPA and treated with 4 nM GSK-LSD1 for 48 hours.
创建时间：
2020-07-02
