Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

ChEBI2014-06-29 更新2026-07-21 收录

免疫调节性T细胞

炎症疾病调控机制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-57682 数据链接链接失效反馈

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Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

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2014-06-29

RNA-Seq JunB WT and KO Tregs Mus musculus. RNA-Seq JunB WT and KO Tregs Mus musculus

免疫调节性T细胞

基因表达谱分析

To understand the mechanisms through which JunB regulates Tregs-mediated immune regulation, we examined the global gene expression profiles in the JunB WT and KO Tregs by performing RNA sequencing (RN

NIAID Data Ecosystem90

TNF activates a distinct cellular program in human regulatory T cells

免疫调节性T细胞

TNF信号通路

Here we show that tumor necrosis factor (TNF) induced in human T-regulatory cells (Treg), as compared to conventional T cells (Tcon), a transcription program highly enriched for typical NF-κB target g

NIAID Data Ecosystem30

Source data for S1 Fig numerical data.

免疫调节性T细胞

肿瘤免疫微环境

Regulatory T cell (Treg) heterogeneity exists in lymphoid and non-lymphoid tissues, but we have limited understanding of context-dependent functions and spatiotemporal regulators of heterogenous Treg

NIAID Data Ecosystem10

APC from pre-diabetic and Sick NOD mice are less efficient at maintaining Foxp3 expression in vitro .

免疫调节性T细胞

自身免疫疾病

CD4+CD25+ T cells from 12–15 week-old Sick NOD mice were cultured overnight in multiple wells, either alone or with irradiated T-cell depleted spleen cells (APC) from B6, pre-diabetic (11 week-old) NO

NIAID Data Ecosystem50

Next Generation Sequencing of Transcriptomes of WT and Transgenic Treg cells to differentiate effect of TIM-3 on Tregulatory cell geneexpression.

免疫调节性T细胞

基因表达调控

Significant differences were found in transcriptional profiles of WT and TIM-3+(GFPHi and GFP Low) cells, suggesting major shifts in metabolic status, cytokine profiles and suppresive capacity of Treg

NIAID Data Ecosystem20

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

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