Comparison of timing of selected medicine switches across countries up to and including 2013.

X =  not switched.
a. In early Australian switches timing differed between the States and Territories, the earliest switch date is shown.
b. Orciprenaline (metaproterenol), a non-selective beta-agonist was switched in the US in 1982, but reversed in 1983 [31].
c. Flavoxate is non-prescription in both Australia and NZ, but marketed in neither.
d. The non-sedating antihistamine switched in the UK in 1983 was terfenadine, which later reverted to prescription medicine following QT prolongation concerns [3].
e. Hydrocortisone 1% with oxytetracycline (but not alone) has long been available without prescription in Japan.
f. Other antibacterial eye preparations have long been available without prescription in these jurisdictions, e.g. sulfacetamide in NZ and Australia, polymyxin and bacitracin in the US, and sulfamethoxazole in Japan.
g. Tranexamic acid was switched in Australia in 2000 but never marketed as a non-prescription medicine and reverted to prescription in 2007 under Trans-Tasman Harmonization.
h. Tranexamic acid in Japan was switched at a lower dose, in combination with other ingredients, and for a different indication to the UK (chloasma not menorrhagia) [32].
i. Oral oxybutynin was previously available without prescription in NZ.
Note: Medicines are oral unless otherwise specified. All vaccines are injected except for the cholera and travellers' diarrhoea vaccine which is oral.
Comparison of timing of selected medicine switches across countries up to and including 2013.