Structure of the sodium channel pore revealed by serial cysteine mutagenesis.
收藏PubMed Central1996-01-09 更新2026-05-02 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC40226/
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资源简介：
The pores of voltage-gated cation channels are formed by four intramembrane segments that impart selectivity and conductance. Remarkably little is known about the higher order structure of these critical pore-lining or P segments. Serial cysteine mutagenesis reveals a pattern of side-chain accessibility that contradicts currently favored structural models based on alpha-helices or beta-strands. Like the active sites of many enzymes of known structure, the sodium channel pore consists of irregular loop regions. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-01-09
