Weight score for genotoxic stress responsive gene selection in the in vivo microarray study (liver, B6C3F1).

1“V” represents values.2“S” represents score. Only the top 20 genes are shown. A full list is attached in Table S3.Detailed scoring rules are described in the supporting information. “Pink cells” represent up-regulation and “blue cells” represent down-regulation.Specificity = (number of total pink cells in GTXs)/(number of total pink cells in GTXs and NGTXs); Ave ratio = average of ratios of all pink cells in GTXs; Positive condition = number of total pink cells in GTXs. Since DEN was duplicated, each pink cell was considered 0.5; Positive chemical = number of GTXs with at least one pink cell; P value was calculated by t test of signal intensity between GTXs and NGTXs in GeneSpring software; Basal represents basal expression level, equals to log10 value of signal intensity of control animals; Reverse change reflects opposite change of gene expression in different treatment groups. Reverse change = number of blue cells in NGTXs - number of blue cells in GTXs; CV% = 100×SD/MEAN% based on the signal intensity of all control animals. Total score = Score of 2× Specificity + Ave ratio + Positive condition + Positive chemical + P value + 0.5× Basal + 0.5× Reverse change + 0.5× CV%.