Whole exome sequencing of murine leukemia and lymphoma

Mouse models of cancer serve as excellent tools to examine the functionality of gene mutations and their contribution to the malignant process. However, it remains unclear whether the genetic events that occur during transformation are similar in mice and humans. In this study, mouse models of hematologic malignancies were used to identify acquired mutations by means of whole exome sequencing. Analysis of the sequencing data revealed similarities in the mutational evolution of mouse and human hematologic malignancies.