A novel Co(II)-based coordination polymer: crystal structure and biological activity

Based on a mixed-ligand strategy, a new coordination polymer with the chemical formula of {[Co2(IMMB)2(bim)]·2DMA}n (1, DMA = N,N-dimethylacetamide) has been successfully synthesized by the reaction of 4,4’-((1H-imidazol-1-yl)methylene)dibenzoic acid (H2IMMB) and Co(NO3)2·6H2O with the presence of benzimidazole as the co-ligand under the solvothermal methods. Furthermore, a green hand grinding technique has been implemented to reduce the particle size of the complex 1 to generate nanoscale 1 (denoted as nano 1 hereafter) with rod-like morphology. Furthermore, the protective of nano 1 on the acute peritonitis complicated peritonitis was evaluated. Firstly, the inhibitory effect of nano 1 on the yigP gene expression was measured by reverse transcription-polymerase chain reaction (RT-PCR), which is vital important for the E. coli viability. Next, the protective ability of nano 1 in the children acute peritonitis complicated peritonitis animal model was evaluated by detecting the content of the inflammatory cytokines through enzyme linked immunosorbent assay (ELISA).