C57BL/6 or B6.NZMSle1/Sle2/Sle3 were treated with 100ug of anti-CD45RB (MB23G2) on days 0,1,3,5,and 7. Mice were sacrificied and spleens were harvested and sorted for untouched CD4+ T cells using nega
While immune checkpoint blockade therapies are commonly utilized during the course of metastatic cancer treatment, much remains unknown regarding the mechanisms underlying individual therapies. CD8+ T
Complement factor H (CFH) regulates complement activation and protect host cells, including tumor cells, from attack by the alternative pathway of complement mediated cytotoxicity. In this study, we a
Tumor microenvironment (TME) is a complex dynamic system with many tumor-interacting components including tumor-infiltrating leukocytes (TILs), cancer associated fibroblasts, blood vessels, and other