Mus musculus Transcriptome or Gene expression. Mus musculus

Renal interstitial fibrosis is an incurable pathological lesion in progressive chronic kidney diseases. Myofibroblasts proliferation and microvascular damage are two important events of RIF and pericyte is one of the major sources of myofibroblasts in kidney. However, the underlying mechanisms remain poorly characterized. Here we present that core fucosylation, a posttranslational modification of proteins, is essential for pericyte activation via regulating of profibrotic and antifibrotic signaling pathway as a hub like target. Exosomes deriving from MSCs specifically reside in obstructed kidney and deliver microRNA34c5p to inhibit CF resulting in reducing pericyte activation and renal fibrosis. Furthermore, we clarify that the ligands and receptors complex assists the entrance of exosomal microRNA34c5p into pericytes.