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Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)

NIAID Data Ecosystem2026-05-02 收录

基于结构的药物设计

抗菌药物研发

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Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)

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创建时间：

2024-10-30

抗菌药物研发

临床前研究

Number of antibacterial agents in preclinical programs worldwide in 2023, by type

Statista60

Heparanase P6 in complex with fragment J40

蛋白质结构解析

基于结构的药物设计

Heparanase P6 in complex with fragment J40 Descriptor: 2-({[(1S)-1-cyclopropylethyl](methyl)amino}methyl)quinazolin-4(3H)-one, Heparanase 50 kDa subunit, Heparanase 8 kDa subunit, ... Authors: Davies,

Protein Data Bank Japan2026-03-04 更新30

Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design

HIV-1整合酶抑制剂

基于结构的药物设计

Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design

NIAID Data Ecosystem10

Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases

抗菌药物研发

β-内酰胺酶抑制剂

Despite major advances in the β-lactamase inhibitor field, certain enzymes remain refractory to inhibition by agents recently introduced. Most important among these are the class B (metallo) enzyme ND

NIAID Data Ecosystem40

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with an inhibitor 617

蛋白质结构解析

基于结构的药物设计

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with an inhibitor 617 Descriptor: (2~{S})-2-[[(2~{S})-6-[[(2~{S})-3-naphthalen-2-yl-2-[[4-[[2-[(11~{Z})-4,7,10-tris(2-hydroxy-

Protein Data Bank Japan2026-03-04 更新20

Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)

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