Pde3b

ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; phosphoprotein binding; INVOLVED IN negative regulation of cAMP/PKA signal transduction; negative regulation of insulin secretion involved in cellular response to glucose stimulus; cellular response to insulin stimulus (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; insulin signaling pathway; purine metabolic pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); intellectual disability (ortholog); polycystic ovary syndrome (ortholog); FOUND IN endoplasmic reticulum (ortholog); Golgi apparatus (ortholog); guanyl-nucleotide exchange factor complex (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine

编码一种表现出3',5'-环状-AMP磷酸二酯酶活性、3',5'-环状-GMP磷酸二酯酶活性、磷酸蛋白结合的蛋白质；参与cAMP/PKA信号转导的负调控；涉及葡萄糖刺激的细胞对胰岛素分泌的负调控；细胞对胰岛素刺激的响应（同源）；参与蛋白激酶A（PKA）信号通路、胰岛素信号通路、嘌呤代谢通路；与慢性阻塞性肺疾病（同源）、智力障碍（同源）、多囊卵巢综合征（同源）相关；存在于内质网（同源）、高尔基体（同源）、鸟苷酸交换因子复合物（同源）；与（+）五味子素B、17β-雌二醇、2,3,7,8-四氯二苯并-对氧偶氮（TCDD）相互作用