Raw and processed data for studying chaperon-client interactions in 12 cancer types.

This data accompanies the paper "Ecological network analysis reveals cancer-dependent chaperone-client interaction structure and robustness", by Geut Galai, Xie He, Barak Rotblat, Shai Pilosof. Published in Nature Communications.<b> </b><b>Please cite the paper when using the data.</b>All users <b>must</b> read the paper to understand how the data were obtained and processed, and their limitations. Data comes without warranty. Licence is <b>CC BY-NC-SA (Attribution-NonCommercial-ShareAlike): </b>This license lets you remix, tweak, and build upon this work non-commercially, as long as you credit the authors and license the new creations under the identical terms.All the computational processes related to data derivation and analysis are in the GutHub repository that accompanies the paper.Raw data (raw.zip)Gene level transcriptome profiling (RNA-Seq) data (in the form of HTSeq - FPKM) that was download from The Cancer Genome Atlas (TCGA) using the Genomic Data Commons Data Portal https://portal.gdc.cancer.gov).Human protein expression data that was downloaded from the string-db.org data base, and from published papers as follows.File: 12192_2020_1080_MOESM4_ESM.xlsx. Source: Bie AS, Cömert C, Körner R, Corydon TJ, Palmfeldt J, Hipp MS, et al. An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space. Cell Stress Chaperones. 2020;25: 407–416. doi:10.1007/s12192-020-01080-6File: 41467_2013_BFncomms3139_MOESM481_ESM.xls. Source: Chae YC, Angelin A, Lisanti S, Kossenkov AV, Speicher KD, Wang H, et al. Landscape of the mitochondrial Hsp90 metabolome in tumours. Nat Commun. 2013;4: 2139. doi:10.1038/ncomms3139File: 12915_2020_740_MOESM8_ESM.xlsx Source: Joshi A, Dai L, Liu Y, Lee J, Ghahhari NM, Segala G, et al. The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis. BMC Biol. 2020;18: 10. doi:10.1186/s12915-020-0740-7File: mmc2.xlsx Source: Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, et al. Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. Cancer Cell. 2019;35: 721–737.e9. doi:10.1016/j.ccell.2019.03.014Processed data (processed.zip)The network data. Rows are chaperones, columns are clients.Source dataFile: Source Data for Figures and Tables.zipThis is the source data underlying the figures and tables, as requested by Nature Communications.