X-ray crystal structure of beta secretase complexed with compound 24
收藏Protein Data Bank Japan2024-11-06 更新2026-03-21 收录
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X-ray crystal structure of beta secretase complexed with compound 24 Descriptor: (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one, BETA SECRETASE 1, IODIDE ION Authors: Edwards, P.D, Albert, J.S, Sylvester, M, Aharony, D, Andisik, D, Callaghan, O, Campbell, J.B, Carr, R.A, Chessari, G, Congreve, M, Frederickson, M, Folmer, R.H.A, Geschwindner, S, Koether, G, Kolmodin, K, Krumrine, J, Mauger, R.C, Murray, C.W, Olsson, L.L, Patel, S, Spear, N, Tian, G. Deposit date: 2007-08-30 Release date: 2007-11-13 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine Beta-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency. J.Med.Chem., 50, 2007
创建时间：
2007-08-30
