High-throughput antibody sequencing allows in-depth insights into human antibody repertoires. To investigate the characteristics of antibody repertoires in patients with chronic HBV infection, we perf

NIAID Data Ecosystem20

Antibody Repertoires in Humanized NOD-scid-IL2Rγnull Mice and Human B Cells Reveals Human-Like Diversification and Tolerance Checkpoints in the Mouse

抗体库分析

B细胞耐受

Immunodeficient mice reconstituted with human hematopoietic stem cells enable the in vivo study of human hematopoiesis. In particular, NOD-scid-IL2Rγnull engrafted mice have been shown to have reasona

Figshare2016-01-19 更新10

Mus musculus strain:BALB/c Raw sequence reads. Mus musculus strain:BALB/c

抗体库分析

免疫状态评估

Article: Accurate and predictive antibodyrepertoire profiling by molecularamplification fingerprintingKhan et al. Sci. Adv. 2016; 2 : e1501371High-throughput antibody repertoire sequencing (Ig-seq) pr

NIAID Data Ecosystem30

Next-generation sequencing analysis of the library CDRs.

免疫组库测序

CDR互补决定区

a Percentage of in-frame CDR sequences before the proofreading panning was estimated by Sanger sequencing of 12~28 sequences per CDR.b Percentage of the designed CDR sequences that were found in NGS a

Figshare2015-12-03 更新20

Performance on the monoclonal repertoire M26.

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