Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine.
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Experimental data from
Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration
dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic
migraine.
Louisiane Lemaire1,2,*, Mathieu Desroches1,2, Martin Krupa1,3, Lara Pizzamiglio5,6, Paolo
Scalmani4, Massimo Mantegazza5,6,7,**
1 Inria Sophia Antipolis Méditerranée Research Centre, MathNeuro Team, Valbonne-Sophia Antipolis,
France.
2 Université Côte d’Azur, Nice, France.
3 Université Côte d’Azur, Laboratoire Jean-Alexandre Dieudonné, Nice, France.
4 U.O. VII Clinical and Experimental Epileptology, Foundation IRCCS Neurological Institute Carlo
Besta, Milan, Italy.
5 Université Côte d’Azur, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia
Antipolis, France.
6 CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis,
France.
7 Inserm, Valbonne-Sophia Antipolis, France.
Corresponding authors:
* louisiane.lemaire@inria.fr
** mantegazza@ipmc.cnrs.fr
https://hal.archives-ouvertes.fr/hal-03191275
创建时间：
2021-06-11
