Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2‑Fluoroallylic Sulfones
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https://figshare.com/articles/dataset/Palladium-Catalyzed_Ring-Opening_Coupling_of_i_gem_i_-Difluorocyclopropanes_for_the_Construction_of_2_Fluoroallylic_Sulfones/9932300
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A Pd-catalyzed ring-opening sulfonylation of gem-difluorocyclopropanes is reported. This protocol involves C–C bond cleavage, β-F elimination, and allylic coupling to form corresponding 2-fluoroallylic sulfones efficiently with Z-selectivity. Different substrates bearing diverse functional groups are tolerated. Moreover, this method is successfully used for the late-stage derivation of several bioactive molecules.
创建时间：
2019-09-20
