Whole transcriptome sequencing identifies increased CXCR2 expression in PNH granulocytes

To clarify the selective advantage of the GPI-AP- cells in paroxysmal nocturnal hemoglobinuria (PNH) patients, RNA-seq was applied to examine functional effects of the PIG-A mutation in human granulocytes. Overall design: RNA seq, 2 PNH patiant''s GPI-AP- granulocyte,2 PNH patiant''s GPI-AP+ granulocyte, 3 Healthy granulocyte