Role of mevalonate pathway intermediates in anticancer effect of statins

ChEBI2018-03-31 更新2026-07-12 收录

他汀类药物抗癌机制

甲羟戊酸途径调控

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-3263 数据链接链接失效反馈

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Role of mevalonate pathway intermediates in anticancer effect of statins

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2018-03-31

MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway [bulkRNA-seq]. MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway [bulkRNA-seq]

癌症分子机制

甲羟戊酸途径调控

The microRNA (miR) miR-874, a potential tumour suppressor, causes cell death via target gene suppression in various cancer types. Mevalonate pathway inhibition also causes cell death in breast cancer.

NIAID Data Ecosystem40

RNA-seq of S. cerevisiae S288C wild-type and S288C-H2 mutant

CRISPR基因编辑转录组

甲羟戊酸途径调控

S. cerevisiae strain S288C was subjected to CRISPR/Cas9 edition in the HMG-CoA reducatase gene using a modified housekeeping promoter ADH1 incorporating the up-stream region of TEF1 promoter (UADH1).

NIAID Data Ecosystem20

Additional file 3 of Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway

神经再生治疗

甲羟戊酸途径调控

Supplementary Material 3

Figshare2025-03-05 更新10

ePoster Vascular Discovery 2020 MDG.pdf

肝脏内质网应激与凋亡

甲羟戊酸途径调控

Hmg-CoA Reductase (Hmgcr) catalyzes the conversion of Hmg-CoA to mevalonate, which is the rate-limiting step in the cholesterol biosynthetic pathway. Hmgcr is the target of statins, which are the fron

HRA Figshare2026-05-15 更新20

Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase

泛素化调控

甲羟戊酸途径调控

Regulation of the sterol-synthesizing mevalonate pathway occurs in part through feedback-regulated endoplasmic reticulum degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-R). In yeast, the

PubMed Central1997-11-25 更新10

Role of mevalonate pathway intermediates in anticancer effect of statins

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