Genomic structural equation modelling of 12 cancers identifies a latent pan-cancer susceptibility factor and shared determinants of carcinogenesis

pan.gzGWAS summary statistics for gSEM-based pan-cancer factor.A1: effect alleleA2: other allele EAS_5e-8.scoreSNP weights used for polygenic risk score (PRS) calculation in the East Asian (EAS) population, derived using the P+T method. The file includes weights for pan-cancer, cross-cancer, and 12 site-specific cancer PRS models, all based on EraSOR-adjusted GWAS summary statistics to reduce bias from sample overlap with the UK Biobank.A1: effect allele score_merged.txt.gzSNP weights used for polygenic risk score (PRS) calculation in the European (EUR) population, derived using the SBayesRC method. The file includes weights for pan-cancer, cross-cancer, and 12 site-specific cancer PRS models, all based on EraSOR-adjusted GWAS summary statistics to reduce bias from sample overlap with the UK Biobank.A1: effect alleleSNP: SNP identifier used in the UK Biobank, formatted as chr:pos:ref:alt, where the genomic position is based on GRCh37.