The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

Protein Data Bank Japan2023-09-20 更新2026-03-21 收录

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The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates Descriptor: 1,2-ETHANEDIOL, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthase, ... Authors: Tsoumpra, M.K, Barnett, B.L, Muniz, J.R.C, Walter, R.L, Ebetino, F.H, von Delft, F, Russell, R.G.G, Oppermann, U, Dunford, J.E. Deposit date: 2013-12-03 Release date: 2014-11-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.43 Å) Cite: The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates To be Published

赖氨酸200与苯丙氨酸239位点突变的法尼基焦磷酸合酶（Farnesyl Pyrophosphate Synthase，FPPS）的催化活性、晶体结构及含氮双膦酸盐抑制效应描述项：1,2-乙二醇、1-羟基-2-(3-吡啶基)亚乙基双膦酸、法尼基焦磷酸合酶作者：Tsoumpra, M.K、Barnett, B.L、Muniz, J.R.C、Walter, R.L、Ebetino, F.H、von Delft, F、Russell, R.G.G、Oppermann, U、Dunford, J.E 提交日期：2013-12-03 发布日期：2014-11-19 最后修改日期：2023-09-20 实验方法：X射线衍射（分辨率1.43埃）引用文献：《赖氨酸200与苯丙氨酸239位点突变的法尼基焦磷酸合酶（FPPS）的催化活性、晶体结构及含氮双膦酸盐抑制效应》，待发表

创建时间：

2013-12-03