Zhang2007 - Mechanism of DNA damage response (Model3)

NIAID Data Ecosystem2026-05-02 收录

DNA损伤机制

p53凋亡信号通路

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https://www.omicsdi.org/dataset/biomodels/BIOMD0000001010 数据链接链接失效反馈

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It's a mechanistic model explaining the impact of p53 on apoptosis decision. This model represents schema 3 of manuscript.

创建时间：

2024-09-02

The telomeric DNA damage response occurs in the absence of chromatin decompaction

端粒成像分析

DNA损伤机制

Telomeres are specialized nucleoprotein structures that protect chromosome ends from DNA damage response (DDR) and DNA rearrangements. The telomeric shelterin protein TRF2 suppresses the DDR, and this

NIAID Data Ecosystem100

Table_11_Reduction of H3K27cr Modification During DNA Damage in Colon Cancer.xlsx

组蛋白巴豆酰化

DNA损伤机制

DNA damage plays an essential role in the initiation and development of colon cancer. Histone crotonylation is a newly discovered post-translational modification that is thought to promote gene expres

NIAID Data Ecosystem40

Theoretical Study of the Tautomerism in the One-Electron Oxidized Guanine−Cytosine Base Pair

DNA损伤机制

量子化学计算

Ionizing radiation on DNA mainly generates one-electron oxidized guanine−cytosine base pair (G+•:C), and in the present paper we study all possible tautomers of G+•:C by using ab initio approaches. Ou

NIAID Data Ecosystem20

Vorinostat Induces Reactive Oxygen Species and DNA Damage in Acute Myeloid Leukemia Cells

白血病靶向治疗

DNA损伤机制

Histone deacetylase inhibitors (HDACi) are promising anti-cancer agents, however, their mechanisms of action remain unclear. In acute myeloid leukemia (AML) cells, HDACi have been reported to arrest g

NIAID Data Ecosystem70

Transcription and DNA Replication Shapes DNA Break Dynamics in Long Neuronal Genes

基因组稳定性

DNA损伤机制

Neural progenitor cells undergo tens of thousands of cell divisions to generate the 80 billion neurons in a human brain. These fast-dividing neural stem and progenitor cells rapidly incorporate somati

NIAID Data Ecosystem20

Zhang2007 - Mechanism of DNA damage response (Model3)

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