Crystal structure of VIM-2 MBL in complex with 1-cyclobutyl-1H-imidazole-2-carboxylic acid

Crystal structure of VIM-2 MBL in complex with 1-cyclobutyl-1H-imidazole-2-carboxylic acid Descriptor: 1-cyclobutylimidazole-2-carboxylic acid, Beta-lactamase class B VIM-2, FORMIC ACID, ... Authors: Li, G.-B, Yan, Y.-H. Deposit date: 2021-01-12 Release date: 2022-01-19 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors. Eur.J.Med.Chem., 228, 2022VIM-2型金属β-内酰胺酶（Metallo-beta-lactamase, MBL）与1-环丁基-1H-咪唑-2-羧酸结合的晶体结构。描述项：1-环丁基咪唑-2-羧酸、B类β-内酰胺酶VIM-2、甲酸等。作者：李 G.-B、严 Y.-H。存入日期：2021-01-12；发布日期：2022-01-19；最后修改日期：2023-11-29。实验方法：X射线衍射（1.6 Å）。引用文献：《结构导向优化1H-咪唑-2-羧酸衍生物以获得强效VIM型金属β-内酰胺酶抑制剂》，《欧洲药物化学杂志》（Eur.J.Med.Chem.），228卷，2022年。