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Dissecting the mechanisms underlying the Cytokine Release Syndrome (CRS) mediated by T Cell Bispecific Antibodies

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP442869
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We performed bulk RNAseq of HUVECs exposed to cytokine-rich supernatant from T cell dependent cytotoxicity assay with CEA-TCB or DP47-TCB (untargeted-TCB; negative control) to study their activation and contribution to cytokine release. Overall design: Supernatants from T cell dependent cytotoxicity assay with DP47-TCB (untargeted-TCB) or CEA-TCB were collected and transferred to HUVECs for 6 hrs. At assay endpoints (6hrs), HUVECs were collected, washed and lysed for bulk RNAseq.
创建时间:
2023-09-19
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