Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid

Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid Descriptor: (1R,3S,4R)-3-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-methylcyclohexane-1-carboxylic acid, Ornithine aminotransferase, mitochondrial, ... Authors: Butrin, A, Zhu, W, Liu, D, Silverman, R. Deposit date: 2021-02-10 Release date: 2021-08-25 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. J.Am.Chem.Soc., 143, 2021

鸟氨酸氨基转移酶（Ornithine Aminotransferase, OAT）与其灭活剂(1S,3S)-3-氨基-4-(二氟亚甲基)环己烯-1-羧酸共结晶数据集。描述物：(1R,3S,4R)-3-[({3-羟基-2-甲基-5-[(膦酰氧基)甲基]吡啶-4-基}甲基)氨基]-4-甲基环己烷-1-羧酸、线粒体鸟氨酸氨基转移酶等。作者：Butrin A、Zhu W、Liu D、Silverman R。沉积日期：2021-02-10，发布日期：2021-08-25，最后修改日期：2024-11-06。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.95埃（Å）。引用文献：《(S)-3-氨基-4-(二氟亚甲基)环己-1-烯-1-羧酸作为人鸟氨酸氨基转移酶选择性灭活剂的显著且意外机制》，发表于《美国化学会志》（J.Am.Chem.Soc.），143卷，2021年