Angiogenesis and vasculogenic mimicry (VM) are thought to be the predominant processes ensuring tumor blood supply during the growth and metastasis of glioblastoma (GBM). Celastrol has potential anti-

NIAID Data Ecosystem40

Structural basis for mTORC1 regulation by the CASTOR1-GATOR2 complex

结构生物学

mTOR信号通路调控

7.77 Å cryo-EM map for GATOR2-Castor1-Sestrin2 complex and coordinates of an AlphaFold predicted model of Sestrin2 bound to one copy of WDR24, two copies of SEH1L and one copy of MIOS docked into the

Figshare2025-07-26 更新30

screen miRNAs specifically regulated by mTORC1 or mTORC2

mTOR信号通路调控

miRNA表达谱分析

To screen miRNAs specifically regulated by mTORC1 or mTORC2, a global miRNA expression profile in MCF-7 cells treated with rapamycin or PP242 (mTORC1/2 kinase inhibitor) was developed using microarray

NIAID Data Ecosystem70

Treatment with LPAAT-β siRNA results in inhibition of phosphorylation of mTOR effector proteins 4E-BP1, S6K, and AKT.

LPAAT-β基因沉默

mTOR信号通路调控

AsPC-1 (A) and MiaPaCa2 (B) cells were treated for 72 hr with 25 nM LP-1, LP-4, non-targeting siRNA (nt), or a mock transfectant (m). Western blots were done with the indicated antibodies to mTOR eff

NIAID Data Ecosystem40

The Rag GTPase regulates the dynamic behavior of TSC downstream of both amino acid and growth factor restriction

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