Pharmacokinetic parameters of indinavir (40 mg/kg orally) after multiple dosage.

The rats received oral administration of indinavir (40 mg/kg) together with 1.5% Tween 80 (vehicle), Sophora extract (0.158 g/kg or 0.63 g/kg), Oxymatrine capsule (45 mg/kg of oxymatrine equivalent), or ethyl acetate (EA) fraction of Sophora extract (0.082 g/kg), twice a day for 7 days, respectively. On the experimental day (day 8), animals were pretreated with corresponding vehicle or tested drugs at 1 h prior to the last dose of indinavir given to all rats for pharmacokinetic study. Values are expressed as mean ± S.E.M. (n = 6–9). Significance is indicated as
*P<0.05,
**P<0.01,
***P<0.001, compared to vehicle control.