Early, individualized recommendations for hospitalized patients with acute kidney injury: A randomized clinical trial

Importance: Acute kidney injury (AKI) is a common complication during hospitalization associated with poor outcomes. Objective: To evaluate whether diagnostic and therapeutic recommendations sent from a Kidney Action Team through the electronic health record improve outcomes among patients hospitalized with AKI, compared to usual care.  Design, Setting, participants: Randomized, clinical trial conducted at two US health systems including seven hospitals.  Hospitalized patients with AKI were randomized between October 29th, 2021, to February 8th, 2024. Final follow-up occurred in February 2024. Intervention: An alert was sent to the Kidney Action Team, consisting of a physician and pharmacist (never directly to the clinical providers) who provided personalized recommendations for patients with AKI in five major categories (general diagnostics, volume, potassium, acid-base, and medications) within 1 hour via a structured note in the electronic health record. The note is immediat..., , , # Data from: Early, individualized recommendations for hospitalized patients with acute kidney injury: A randomized clinical trial [https://doi.org/10.5061/dryad.sqv9s4ncs](https://doi.org/10.5061/dryad.sqv9s4ncs) ## Description of the data and file structure The data was collected during the course of the Kidney Action Team clinical trial, conducted at Yale and Johns Hopkins from 2022 to 2024. ### Files and variables #### File: KAT-AKI_limited_dataset.04-23-26.csv **Description:** Analytic dataset for the KAT AKI trial. ##### Variables * age: Age of the patient (rounded to nearest year. Age above 90 is listed as 90 with a binary flag - see below) * femalesex: 1 = female * hospital: in order to account for stratified randomization * ckd_pmhx: past medical history of chronic kidney disease * chf_pmhx: past medical history of congestive heart failure * dm_pmhx: past medical history of diabetes * htn_pmhx: past medical history of hypertension * cirrhosis_pmhx: past medical history ..., This research was granted a waiver of informed consent by the Yale IRB, under 45 CFR § 46.116. To ensure participant privacy, the dataset was de-identified by removing all 18 standard categories of direct personal identifiers. Temporal data (such as dates of enrollment or clinical visits) were converted to elapsed days from a baseline index date (Day 0) rather than absolute dates. Participant ages >=90 years were recoded into a single top-coded category. ,