<b>Adenosine-mediated immune evasion and virulence</b>

Collectively, this research suggests a direct correlation between enzymatic activity and enhancement of bacterial survival and virulence. <i>S. suis</i> 5’-nucleotidases synergistically contribute to the generation of adenosine, influencing susceptibility within blood and PMNs, and enhancing survival within blood and organs <i>in vivo. </i>This elucidation of their integral functions in the pathogenic process of <i>S. suis</i> not only enhances our comprehension of bacterial virulence mechanisms, but also illuminates new avenues for therapeutic intervention aimed at curbing <i>S. suis</i> infections.