Visible-Light-Mediated Trifluoroalkylation of Isoquinolines via Three-Component Minisci-Type Reaction

A sustainable photocatalytic approach has been established
for
trifluoroalkylation of isoquinoline via a three-component Minisci-type
reaction using a green solvent. The polarity reversal radical cascade
strategy renders the selective addition of an electrophilic CF3 radical to an olefin to forge a nucleophilic C-centered radical. This multicomponent approach is operationally
simple and environmentally benign with various functional groups,
viz. aldehydes, acetals, amides, and halides. Mechanistic investigations
were carried out to elaborate the reductive quenching catalytic pathway.