Cooperativity between classical DNA end-joining and p53 in carboplatin resistance in human ovarian cancer cells

Targeting classical end-joining signaling pathway might be a potential therapeutic strategy to overcome the chemotherapeutic drug resistance and increase the potency of cancer treatment To investigate the key regulator of carboplatin-resistance in human ovarian cancer cells, DNA repair status of 3 different human ovarian cancer cells with different degree of carboplatin-resistance was compared.