α‑Arylation of Saturated Azacycles and N‑Methylamines via Palladium(II)-Catalyzed C(sp3)–H Coupling

Pd­(II)-catalyzed α-C­(sp3)–H arylation of pyrrolidines, piperidines, azepanes, and N-methylamines with arylboronic acids has been developed for the first time. This transformation is applicable to wide arrays of pyrrolidines and boronic acids, including heteroaromatic boronic acids. A diastereoselective one-pot heterodiarylation of pyrrolidines has also been achieved.