Pharmacologic inhibition of host phosphodiesterase-4 improves isoniazid mediated clearance of Mycobacterium tuberculosis

ChEBI2016-06-10 更新2026-07-12 收录

结核病治疗

宿主导向疗法

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-83188 数据链接链接失效反馈

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Pharmacologic inhibition of host phosphodiesterase-4 improves isoniazid mediated clearance of Mycobacterium tuberculosis

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2016-06-10

Computational approach identifies protein off-targets for Isoniazid-NAD adduct: hypothesizing a possible drug resistance mechanism in Mycobacterium tuberculosis

结核病治疗

药物耐药性

Isoniazid is an important antitubercular molecule identified as a drug of choice in tuberculosis treatment. As such, INH is an inactive prodrug; it acquires an active conformation by forming an adduct

DataCite Commons2020-08-27 更新310

Additional file 4: of The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy

结核病治疗

细菌遗传学

f-SNP data. All collected and calculated information for the detected f-SNPs. (CSV 186 kb)

Figshare2017-04-20 更新70

Metformin alters human host responses to Mycobacterium tuberculosis in-vitro and in healthy human subjects [PBMC RNA-Seq]

结核病治疗

免疫反应

Metformin, the most widely administered diabetes drug, has been proposed as a candidate for host directed therapy for tuberculosis although very little is known about its effects on human host respons

NIAID Data Ecosystem50

江等人 Sesamol manuscript.xlsx

细菌感染

宿主导向疗法

肠致病性大肠杆菌（ExPEC）存在于肠道外时，会构成严重的人畜共患威胁，导致严重感染和各种宿主之间的潜在交叉传播。不断升级的抗菌素耐药性问题对临床细菌感染的治疗提出了挑战，需要制定创新策略。制定解决细菌感染的新方法至关重要。利用宿主作用抗菌化合物（HAC）的宿主导向疗法（HDT）已成为一种有价值的策略，通过关注宿主细胞内的宿主-病原体相互作用和细菌生存策略来应对细菌挑战。在这项研究中，

DataCite Commons2024-09-03 更新90

Targeting glycolysis reduces infection and dampens inflammation in a host-directed therapy for dengue

免疫代谢

宿主导向疗法

Monocytes are the key mediators of inflammatory responses in virus patients, and are also the only blood cell type that supports productive infection both in vitro and in vivo. In this study, we asses

NIAID Data Ecosystem60

Pharmacologic inhibition of host phosphodiesterase-4 improves isoniazid mediated clearance of Mycobacterium tuberculosis

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