Transcriptional profiles associated with coronary artery disease in Type 2 diabetes mellitus

Coronary artery disease (CAD) is a common complication of Type 2 diabetes mellitus (T2DM). Understanding the pathogenesis of this complication is essential in both diagnosis and management. Thus, this study aimed to characterize the presence of CAD in T2DM using molecular markers and pathway analyses. Total RNA from peripheral blood mononuclear cells (PBMCs) underwent whole transcriptomic profiling using the Illumina HumanHT-12 v4.0 expression beadchip. Differential gene expression with gene ontogeny analyses was performed, with supporting correlational analyses using weighted correlation network analysis (WGCNA) The study is a sex- and age-frequency matched case-control design comparing 23 unrelated adult Filipinos with T2DM-CAD to 23 controls (DM with CAD). The experiment used two microarray platforms to generate the data used for the published article (PMID: 38706700). The data from these platforms were merged and then analyzed. One of the platforms, Illumina, was used on 56 samples (Healthy n=15, DM with no CAD n=21, DM with CAD n=20), while the platform Affymatrix was used on 13 samples (Healthy n=8, DM with no CAD n=2, DM with CAD n=3). UPDATE: [Sept-24-2025] Sample 'sample group': "DM" changed to "DMCAD" (DM with CAD) "no DM" changed to "DMnoCAD" (DM with no CAD) Sample 'comorbidity': 'with Retinopathy" changed to "with CAD" 'with no Retinopathy" changed to "with no CAD" 'healthy" changed to "NA"