Structure of full length human AMPK (a2b1g1) in complex with a small molecule activator MSG011

Structure of full length human AMPK (a2b1g1) in complex with a small molecule activator MSG011 Descriptor: (5S,6R,7R,9R,13cR,14R,16aS)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5H,13cH-5,9-epoxy-4b,9a,1 5-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol, 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, ... Authors: Ovens, A.J, Gee, Y.S, Ling, N.X.Y, Waters, N.J, Yu, D, Scott, J.W, Parker, M.W, Hoffman, N.J, Kemp, B.E, Baell, J.B, Oakhill, J.S, Langendorf, C.G. Deposit date: 2021-05-21 Release date: 2022-06-29 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator. Biochem.J., 479, 2022

全长人类腺苷酸活化蛋白激酶（AMP-activated protein kinase, AMPK）(a2b1g1) 与小分子激活剂MSG011结合的复合物结构。描述符：(5S,6R,7R,9R,13cR,14R,16aS)-6-甲氧基-5-甲基-7-(甲氨基)-6,7,8,9,14,15,16,16a-八氢-5H,13cH-5,9-环氧-4b,9a,15-三氮杂二苯并[b,h]环壬[1,2,3,4-jkl]环戊[e]-as-茚并-14-醇；5'-腺苷一磷酸激活蛋白激酶催化亚基α-2；5'-腺苷一磷酸激活蛋白激酶亚基β-1等。作者：Ovens, A.J.、Gee, Y.S.、Ling, N.X.Y.、Waters, N.J.、Yu, D.、Scott, J.W.、Parker, M.W.、Hoffman, N.J.、Kemp, B.E.、Baell, J.B.、Oakhill, J.S.、Langendorf, C.G.。存储日期：2021-05-21；发布日期：2022-06-29；最后修改日期：2024-10-23。实验方法：X射线衍射（分辨率2.95 Å）。引用文献：《AMPK激活剂SC4的结构功能分析及强效泛AMPK激活剂的发现》，《Biochem.J.》，479卷，2022年。