Crystal Structure of DH475 Fab in complex with Man9

Crystal Structure of DH475 Fab in complex with Man9 Descriptor: DH475 Fab heavy chain, DH475 Fab light chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Finkelstein, M, Fera, D. Deposit date: 2022-06-01 Release date: 2022-10-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Analysis of two cooperating antibodies unveils immune pressure imposed on HIV Env to elicit a V3-glycan supersite broadly neutralizing antibody lineage. Front Immunol, 13, 2022DH475抗原结合片段（Fab）与九甘露糖（Man9）复合物的晶体结构 结构描述：DH475 Fab重链、DH475 Fab轻链，以及α-D-吡喃甘露糖-(1→2)-α-D-吡喃甘露糖-(1→2)-α-D-吡喃甘露糖-(1→3)-[α-D-吡喃甘露糖-(1→2)-α-D-吡喃甘露糖-(1→3)-[α-D-吡喃甘露糖-(1→2)-α-D-吡喃甘露糖-(1→6)]α-D-吡喃甘露糖-(1→6)]β-D-吡喃甘露糖-(1→4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖；作者：Finkelstein M、Fera D；提交日期：2022-06-01；发布日期：2022-10-12；最后修改日期：2024-10-16；实验方法：X射线衍射（2.9 Å）；引用文献：《两种协同抗体的分析揭示HIV包膜蛋白为诱导V3-聚糖超位点广谱中和抗体谱系所施加的免疫压力》，《Frontiers in Immunology》，2022年，第13卷