Effects of interleukin-4 receptor blockade in experimental conjunctivitis evoked by skin inflammation. Effects of interleukin-4 receptor blockade in experimental conjunctivitis evoked by skin inflammation

To characterize conjunctivitis and the effects of IL-4Ra signaling at the transcriptomic level, we performed RNA sequencing (RNA-Seq) on conjunctival tissues in OVA-challenged mice that received isotype or anti-IL-4Ra treatment, as well as control mice that were ocularly challenged with PBS (MC903+OVA/PBS) Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of conjunctiva tissues from three groups (n=5/group)