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Super-enhancer-driven PPP1R15B/CReP, regulated by C/EBPβ and YY1, is oncogenic in multiple myeloma. Super-enhancer-driven PPP1R15B/CReP, regulated by C/EBPβ and YY1, is oncogenic in multiple myeloma

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NIAID Data Ecosystem2026-03-14 收录
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We identified a novel super-enhance-driven oncogene PPP1R15B overexpressed in multiple myeloma as compared to normal plasma cells and B lymphoma cells. We used PPP1R15B specific shRNAs to study its function. Overall design: Comparative gene expression profiling analysis of RNA-seq data for H929 cells and its KD derivatives (shPPP1R15B).

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2022-09-16
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