Transmission blocking activity of sera of different bleeds at various time points from baboons immunized with CH-rPfs48/45 in Montanide ISA-51.

*PMFA was done with sera collected on 12/10/2007 (1 mo post primary immunization), 01/10/2008 (1 mo post 1st boost, 02/21/2008 (15 d post 2nd boost), 03/06/2008 (1 mo post 2nd boost), and 05/05/2008 (3 mo post 2nd boost). The geometric mean of oocyst numbers/midgut in the presence of individual pre-immune sera were 22.24 (Pan 3104), 18.43 (Pan 3140), 22.1 (Pan 3163), 6.31 (Pan 3275), and 19.7 (Pan 3313), respectively. Numbers within parenthesis represent total number of infected mosquitoes/total number of mosquitoes dissected for each feed.