Supporting data for "Elucidating Coronavirus and Virus-host Interaction in Bat and Human Intestinal Organoids"

In contrast to various pathologies in human coronavirus infections, bats appear to host coronaviruses in an asymptomatic manner, indicating a distinct profile of virus-host interaction in bats. Moreover, coronaviruses, show enteric tropism in humans and animals, especially in bats, as most bat coronaviruses were identified from fecal specimens.The lack of a robust and biological-relevant in vitro model has been a hurdle for studying numerous bat coronaviruses and elucidating virus-host interactions in human and bat cells. We conducted a series of studies to investigate coronavirus infections and virushost interaction in bat and human intestinal organoids.