Oral microbiota altered in Parkinson disease with mild cognitive impairment

Cognitive impairment (CI) is a common complication of the non-motor symptoms in PD, including PD with mild cognitive impairment (PD-MCI) and PD dementia (PDD). The pathogenesis of PD-MCI is not absolutely clarified. Previous studies have reported the presence of oral dysbiosis in PD and Alzheimer's Disease patients. This study aimed to investigates the differences of oral microbiota among PD-MCI, PD patient with normal cognition (PD-NC) and healthy control (HC) groups, providing a basis for the diagnosis and treatment of PD-MCI.