Molecular quantum nanosensors functioning in living cells

Quantitatively mapping temperature within living cells is essential for understanding subcellular biophysical processes; however, existing intracellular quantum sensors such as nanodiamonds with nitrogen-vacancy centers, quantum dots and fluorescent proteins face limitations in material heterogeneity, cytotoxicity, and thermometric specificity. Here, we present molecular quantum nanosensors (MQNs) as a next-generation platform for intracellular quantum sensing. MQNs embed pentacene molecular spin qubits within para-terphenyl nanocrystals coated with Pluronic F127, yielding a coherent spin system with molecular-level uniformity and long spin coherence times under physiological conditions. By chemically suppressing hyperfine interactions, we enhance spectral resolution and demonstrate spatially resolved absolute temperature sensing inside the nuclei of living cells. MQNs thus offer a chemically tunable, biologically compatible platform for quantum-level detection of thermal and biochemica..., , , # Molecular quantum nanosensors functioning in living cells

Experimental dataset for the manuscript entitled \"Molecular Quantum Nanosensors Functioning in Living Cells\".

## Description of the data and file structure

The compressed archive is organized by figure number. Each folder contains the underlying data used to generate the corresponding figure panels in the manuscript and Supplementary Materials (Figs. 1–5 and Figs. S1–S16).

Recommended structure:

For T1 and T2 measurements, exponential fitting was applied for the estimation of relaxation time. For Rabi measurements cos fitting was applied for the estimation of Rabi frequency.

Abbreviations (used across files):

MQN200 / MQN500: molecular quantum nanosensors particle sizes 200nm / 500nm

**Figure-by-figure data contents and variables**

**Figure 1** — Schematics and extracellular ODMR/pulsed ODMR characterization

* File: Fig1.xlsx
* Sheet: Fig1D — Example CW-ODMR spectrum (extracellular).
* Variables (as labeled in s...