Cox proportional hazards (PH) models were used to examine the association between patient survival and four subtypes after adjusting for patient age at diagnosis as well as 1p/19q status whenever applicable.

Shown are Hazard Ratios (HRs) plus 95% confidence intervals (CI) and associated p-values. Significant p-values (<0.05) are shown in bold font. For the Cox PH models, Proneural was used as the reference group for the subtype variable, patient age was dichotomized as <55 or ≥55 with <55 as the reference group, and no deletion in 1p/19q status was used as the reference group. Cox PH multivariate analysis was performed for all cases, cases with Astrocytoma, cases with GBM and cases with Oligodendrogliomas, respectively. We note that 1p/19q deletion is present only in Oligodendrogliomas; hence, 1p/19q deletion status was not adjusted for in cases with Astrocytoma or GBM.