Clinical scores before and after multi-nodal DBS

Background
Mixed and complex movement disorders represent significant challenges for surgical treatment. These disease states are likely the result of combined or complex network pathologies affecting multiple pathways1-4. Until recently, attempts to treat complex movement disorders with deep brain stimulation (DBS) have primarily focused on stimulating a single deep target to address patients’ most severe symptoms5-14. However, a multi-nodal targeting approach for DBS by simultaneously stimulating more than one pair of homologous nuclei could be a more effective treatment strategy. Here, we present the technique and initial case series of utilizing multi-nodal stimulation for mixed and complex movement disorders.
Methods
An initial cohort of fifteen mixed and complex movement disorder patients presenting to Stanford University underwent a multi-nodal stimulation approach. In these patients, the multiple (i.e. > 2) simultaneous deep targets were implanted through only 2 burr holes an..., An initial cohort of fifteen mixed and complex movement disorder patients presenting to Stanford University underwent a multi-nodal stimulation approach. In these patients, the multiple (i.e. > 2) simultaneous deep targets were implanted through only 2 burr holes and connected to a single 32-channel pulse generator. Clinical scores including Unified Parkinson's Disease Rating Scale (UPDRS) and Clinical Rating Scale for Tremor (CRST) were taken from chart review of visits before and after surgery., , # **Utilizing Multi-nodal Deep Brain Stimulation for Treatment of Complex Movement Disorders: Clinical Scores Before and After Surgery**

[https://doi.org/10.5061/dryad.qv9s4mwp2](https://doi.org/10.5061/dryad.qv9s4mwp2)

Fifteen patients were assessed before and after implantation of 3-4 directional deep brain stimulation leads targeting two (usually bilateral) distinct nuclei to address multiple dominant movement disorder symptoms. Clinical scores from before and after implantation were conducted by licensed physicians in clinic and pulled from patient charts.

## Description of the data and file structure

Here we include a tabulation of the clinical scores recorded from before and after implantation, these being Unified Parkinson's Disease Rating Scale (UPDRS) and Clinical Rating Scale for Tremor (CRST). These are marked respectively for each patient. Also included are the patients' unique identifiers, sex, movement disorder diagnoses, and DBS targets corresponding to \"Utilizing Mul...