Enantioselective Total Syntheses of Akuammiline Alkaloids (+)-Strictamine, (−)-2(<i>S</i>)‑Cathafoline, and (−)-Aspidophylline A

The akuammiline alkaloids are a family of natural products that have been widely studied for decades. Although notable synthetic achievements have been made recently, akuammilines that possess a methano­quinoliz­idine core have evaded synthetic efforts. We report an asymmetric approach to these alkaloids, which has culminated in the first total syntheses of (−)-2­(S)-cathafoline and the long-standing target (+)-strictamine. Moreover, the first enantioselective total synthesis of aspidophylline A is described.