Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to a variety of infectious agents [EBV B-cells]

We investigated transcriptional responses following in vitro stimulation of EBV-B cells derived from a patient with inherited c-Rel deficiency. Overall design: RNA sequencing was performed on EBV-B cells from a patient with?AR c-Rel deficiency,?either non-transduced (NT), or transduced with an?empty retrovirus (EV), or encoding the wild type c-Rel (WT), 2 hours after activation with PDBu.