Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-747 1-(4-chlorophenyl)-1H-imidazole

Protein Data Bank Japan2024-03-06 更新2026-03-21 收录

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Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-747 1-(4-chlorophenyl)-1H-imidazole Descriptor: 1-(4-CHLOROPHENYL)-1H-IMIDAZOLE, DIMETHYL SULFOXIDE, Polymerase acidic protein Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2016-02-25 Release date: 2017-02-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published

甲型流感病毒WILSON-SMITH/1933（H1N1）亚型聚合酶酸性蛋白（Polymerase acidic protein, PA）与片段命中物EBSI-747 1-(4-氯苯基)-1H-咪唑结合的晶体结构。描述符：1-(4-氯苯基)-1H-咪唑、二甲基亚砜、聚合酶酸性蛋白。作者：西雅图传染性疾病结构基因组学中心（Seattle Structural Genomics Center for Infectious Disease, SSGCID）。提交日期：2016-02-25。发布日期：2017-02-22。最后修改日期：2024-03-06。实验方法：X射线衍射，分辨率2.2埃（Å）。引用文献：通过饱和转移差谱核磁共振（STD NMR）进行片段筛选可识别抗甲型流感病毒聚合酶PA的新型位点结合剂，待发表

创建时间：

2016-02-25