Low osmotic pressure induces calcium response states

Osmotic pressure is critical for maintaining cellular homeostasis, but the mechanisms underlying osmotic responses remain incompletely understood. We show that acute osmotic changes regulate intracellular calcium concentration in three distinct modes. In addition, low osmotic pressure induces calcium flux from the endoplasmic reticulum through ryanodine receptors and propagates calcium signals to neighboring cells through gap junctions. Here, we represented raw data of calcium response modes under different conditions.