Role of obesity in reducing the risk of mortality in sepsis: a meta-analysis of observational studies

In this research, We evaluated obesity, obesity and mortality in patients with septicemia, increases the mortality risk in sepsis and obese patients. We used data sources, such as PubMed, Embase, and the Cochrane Library, without language restrictions. In this project, a prospective population study was used to compare septicemia, obesity group and healthy control group, and to analyze the disability rate and mortality rate of septicemia and obesity group. The risk of deviation was evaluated by Newcastle Ottawa quality Assessment scale (New Caussley Review Scale Scale, NOS). In data synthesis, data with odds ratio (OR) and 95% confidence interval (CI) are collected for Meta analysis, additionally, publication bias was investigated using a funnel plot. The pooled prevalence of mortality in patients with sepsis and obesity (this included 23,358 individuals) was 22.2% (95% CI: 14.2%-30.2%; I2=99.3%; P<0.001). Eight cohort studies investigated survival in hospitalized patients with obesity and sepsis, and pooled analysis showed decreased mortality (OR=0.73; 95% CI: 0.60-0.89; I2=71.9%; P<0.001). However, in ICU (ICU), the proportion of patients with septicemia and obesity was reduced. (OR=0.71; 95% CI: 0.56-0.91; I2=29.6%; P=0.006) but was not linked to a higher chance of dying in a hospital (OR=0.75; 95%CI: 0.55-1.03; I2=80.7%; P=0.077). At follow-up, there was no change in 30-day mortality, but there was a reduction in mortality at the 1-year follow-up. From this meta-analysis, it was found that there was a 27% reduction in mortality in patients with sepsis and obesity, which may confirm the obesity paradox. More prospective trials and mechanistic studies are required to validate this hypothesis.