Replication package: Screen-Detected and Diagnostic Breast Cancers Show Distinct Treatment Pathways and Quality Indicator Performance

This package documents the analyzed dataset for the article Screen-Detected and Diagnostic Breast Cancers Show Distinct Treatment Pathways and Quality Indicator Performance (Bielčiková Z, Tichopád A, Rybář M, Petráková K, Rožánek M, Mothejlová K, Dušek L, Donin G. Study. A retrospective nationwide cohort of 42,380 women aged 45 or older with a first invasive breast cancer (ICD-10 C50) diagnosed in the Czech Republic in 2017-2024. The study links the Czech National Cancer Registry, the National Registry of Reimbursed Health Services and the national mortality data. Screen-detected and diagnostically detected cancers are compared in time to multidisciplinary team discussion and to treatment, first-line treatment, centralization in Comprehensive Cancer Centres, regional variation and survival. Contents. The package describes the structure of the analyzed data and the settings of the analysis. It contains no individual-level data and no analysis code. docs/codebook_analysis_dataset.csv: variables of the analysis dataset (one row per C50 tumour record) docs/codebook_event_log.csv: variables of the event log (one row per claim item or event) docs/codelists.csv: procedure, ATC and ICD-10 codes behind the definitions (Supplementary Table S14 of the article) docs/analysis_settings.csv: cohort criteria, time windows, definitions and statistical settings, with references to the article README.md, LICENSE, CITATION.cff Data availability. The individual-level data come from the National Health Information System of the Czech Republic, which does not permit their public release. Access may be requested from the Institute of Health Information and Statistics of the Czech Republic (ÚZIS ČR, https://www.uzis.cz). Aggregated outputs from the same sources can also be requested through the NZIS synthetic data system of ÚZIS (https://www.nzip.cz/synteticka-data): scripts developed on synthetic data with the structure of NZIS are run by ÚZIS on the primary data. Licence. CC BY 4.0. Funding. This research was supported by the Grant of the Operational Programme Jan Amos Komenský (OP JAK) with project AGEING-CZ No. CZ.02.01.01/00/23_025/0008743. Contact. Zuzana Bielčiková (corresponding author of the article), Charles University and General University Hospital in Prague, [e-mail]; Gleb Donin (analysis), Czech Technical University in Prague, [e-mail].