Formulas and signal detection thresholds for ROR, PRR, BCPNN, and MGPS.

Notes: a, number of reports containing both the target drug and the target adverse drug reaction; b, number of reports containing the target drug but associated with other adverse drug reactions; c, number of reports containing the target adverse drug reaction but associated with other drugs; d, number of reports containing other drugs and other adverse drug reactions. Abbreviations: 95%CI, 95% confidence interval; N, the number of reports; χ2, chi-squared; IC, information component; IC025, the lower limit of 95% CI of the IC; E(IC), the IC expectations; V(IC), the variance of IC; EBGM, empirical Bayesian geometric mean; EBGM05, the lower limit of 95% CI of EBGM. (XLSX)